Artists
- Nabil Kanso – painter
- Sam Maloof – woodworker
Beauty pageant contestants
Entertainment personalities
- Paul Anka – Singer, songwriter, actor, producer
- Jenna Dewan – actress
- Shannon Elizabeth – actress
- Lili Estefan – Cuban-American television personality, niece of Emilio Estefan
- Jamie Farr – actor (sitcom M*A*S*H)
- Khrystyne Haje – actress, (sitcom Head of the Class)
- Hank the Angry Drunken Dwarf – radio and television personality
- Salma Hayek – Mexican-American actress
- Dan Jbara – television and film producer
- Gregory Jbara – television and film actor
- Casey Kasem – radio personality American Top 40 franchise and voiceover actor (cartoon series Scooby Doo, Transformers)
- Kerri Kasem – radio and television host (daughter of Casey Kasem)
- Mario Kassar – filmmaker, founder of Carolco Pictures
- Catherine Keener – actress
- Alek Keshishian – film director
- Callie Khouri – Oscar-winning screenwriter
- Emile Kuri – Mexican-born American Oscar-winning art director
- Frank Lackteen – actor
- John Leguizamo – actor (maternal grandfather was Lebanese)
- Peter Macdissi – film and television actor
- Terrence Malick – filmmaker
- Wentworth Miller – actor
- George Nader – actor, uncle of Michael Nader
- Michael Nader – actor, All My Children
- Kathy Najimy – actress
- George Noory – radio host, (radio program Coast To Coast AM)
- Michael Nouri – actor, film Flashdance
- Zoe Saldana – Dominican-American actress
- Elie Samaha – film producer
- Tom Shadyac – film director
- Tony Shalhoub – actor, (sitcom Monk).
- Haaz Sleiman – actor (series Nurse Jackie; film The Visitor)
- Danny Thomas – actor
- Marlo Thomas – actress
- Vince Vaughn – actor (Lebanese grandfather)
- Amy Yasbeck – actress
Fashion designers
- Joseph Abboud – fashion designer
- Reem Acra – fashion designer
Musicians
- Paul Anka – Canadian-American singer, songwriter, and actor (both parents of Lebanese descent)
- Ron Affif – jazz guitarist and musician
- Nadia Azzi – pianist
- Jack Barakat – guitarist of the American band All Time Low
- Dick Dale – rock guitarist and surf music pioneer
- John Dolmayan – Lebanese-American of Armenian descent, drummer of band System of a Down
- Mohammed El-Bakkar – tenor singer, oud player, and conductor
- Emilio Estefan – Cuban-American musician and producer; husband of Gloria Estefan
- Emile Ghantous – songwriter, musician, music producer
- Sammy Hagar – rock musician
- Paul Jabara – composer
- Soraya – Colombian-American singer
- Serj Tankian – Lebanese-American of Armenian descent, lead singer of band System of a Down
- Tiffany – singer
- Tiny Tim – folk singer
Business
- Magid Abraham – market research expert and businessman
- Malouf Abraham, Jr. – businessman
- Clifford Antone – founder of Antone’s blues club in Austin, Texas
- Thomas J. Barrack, Jr. – businessman and founder of Colony Capital
- Debra Cafaro – CEO of Ventas Inc. a healthcare real estate investment trust
- Charles Elachi – director of Jet Propulsion Laboratory
- Tony Fadell – product development manager at Apple Inc.
- Frédéric Fekkai – French-American hairdresser and founder of Frédéric Fekkai salons and hair products
- Alec Gores – entrepreneur
- Tom Gores – founder and CEO of Platinum Equity.
- Joseph J. Jacobs – former chairman and founder of the Jacobs Engineering Group
- Joe Jamail – attorney and businessman
- George Joseph – founder of Mercury Insurance Group
- John J. Mack – former CEO of investment bank Morgan Stanley (2005 – 2009)
- George J. Maloof, Jr. – businessman and owner of the Sacramento Monarchs, Sacramento Kings and the Palms Casino Resort in Las Vegas
- George J. Maloof, Sr. – businessman and former owner of the Houston Rockets
- Manuel Moroun – businessman and the owner of the Ambassador Bridge
- Fares D. Noujaim – business executive
- Jacques Nasser – former business executive
- Paul Orfalea – founder of Kinko’s
- Madeleine A. Pickens – business executive
- Richard E. Rainwater – investor and fund manager
- Joe Robbie – attorney and original owner of the Miami Dolphins
- Moose Scheib – founder and CEO of LoanMod.com
- Jean Succar Kuri – businessman
- Robert Khuzami – former director U.S. Securities and Exchange Commission
Education/Academic
- Joseph Aoun – president of Northeastern University
- Robert Khayat – chancellor of the University of Mississippi
History
- Philip Khuri Hitti – historian of Arab culture and history
- Akram Fouad Khater, professor, author, expert on Lebanese-American Studies
Journalism
- Tamsen Fadal – television journalist
- Brigitte Gabriel – journalist
- Octavia Nasr – former television journalist for CNN
- Walid Phares – security and anti-terrorism expert
- Anthony Shadid – foreign correspondent for The New York Times and earlier The Boston Globe
- Helen Thomas – journalist who has covered every U.S. President from 1961 to 2010
Medicine
- Amin J. Barakat – physician, known for the diagnosis Barakat syndrome
- Michael DeBakey – surgeon
- George Hatem – (‘”Ma Haide”‘) one of the founders of the public health system in the People’s Republic of China
- Alan R. Malouf – society dentist
- Charles Sophy – psychiatrist
Military
- John Abizaid – retired General in the United States Army.
- James Jabara – first American jet ace.
- George Joulwan – retired U.S. Army General
- Michael A. Monsoor – U.S. Navy SEAL awarded Medal of Honor after being killed during the Iraq War
Activists
- Candy Lightner – activist and founder of Mothers Against Drunk Drivers
- James Zogby – founder of Arab-American Institute
- John Zogby – pollster founder of Zogby International
Politicians
- James Abdnor – former U.S. Senator and U.S. Representative from South Dakota
- James Abourezk – former U.S. Senator from South Dakota
- Malouf Abraham, Sr. – politician and businessman
- Spencer Abraham – former U.S. Senator from Michigan
- Victor G. Atiyeh – former Governor of Oregon
- John Baldacci – former Governor of the State of Maine
- Charles Boustany – U.S. Representative from Louisiana
- Chris Greeley – former Maine state representative
- Philip Habib – former U.S. Ambassador and envoy
- Darrell Issa – U.S. Representative from California
- Chris John – former U.S. Representative from Louisiana
- Abraham Kazen, Jr. – former U.S. Representative from Texas
- Ray LaHood – U.S. Transportation Secretary and former U.S. Representative from Illinois
- Manuel Maloof – former U.S. government official and businessman
- George J. Mitchell – former U.S. Senator from Maine
- Toby Moffett – former U.S. Representative from Connecticut
- Ralph Nader – political activist and former U.S. presidential candidate (Green Party)
- Mary Rose Oakar – former U.S. Representative from Ohio
- Jeanine Pirro – politician, judge and television host
- Nick Rahall – U.S. Representative from West Virginia
- Edmund Reggie – judge and politician
- Selwa Roosevelt – former U.S. government official
- Donna Shalala – former U.S. Secretary of Health and Human Services
- John E. Sununu – former U.S. Senator and U.S. Representative from New Hampshire
- John H. Sununu – former White House Chief of Staff; former Governor of New Hampshire
- Suzanne Haik Terrell – former Louisiana Elections Commissioner
Other personalities
- Joseph Farah – author and journalist
- Adele Khoury Graham – educator and former first lady of the State of Florida
- Victoria Reggie Kennedy – attorney and widow of U.S. Senator Edward Kennedy
- Timothy Massad – U.S. Treasury Department official and corporate lawyer
- Nassim Nicholas Taleb – best-selling author, risk expert and statistician, university professor, and former trader and business person
Sciences
- Hassan Kamel Al-Sabbah – Lebanese-American technology innovator
- Elias Corey – 1990 Nobel Prize winner in Chemistry
- Michael Debakey – doctor and heart surgeon
- Charles Elachi – Director of NASA Jet Propulsion Labs
- Christa McAuliffe – secondary school teacher and first American civilian selected to be an astronaut; perished in the Space Shuttle Challenger disaster. Great niece of historian Philip Khuri Hitti
Athletes
- Skandor Akbar – former professional wrestler
- David Azzi – professional American football player
- Samir Bannout – former professional bodybuilder and winner of Mr. Olympia title in 1983
- Terry Brunk – (aka “Sabu”) professional wrestler
- Liz Carmouche – mixed martial artist
- Doug Flutie – former professional American football player
- Matt Freije – ex-NBA player and member of Lebanon national basketball team
- John Grabow – MLB pitcher for the Chicago Cubs
- Ryan Kalil – professional American football player
- Joe Lahoud – former professional baseball player
- Bobby Rahal – professional car racer and team owner
- Soony Saad – professional soccer forward player
- Damien Sandow – professional American wrestler in the WWE
- Rony Seikaly – former professional basketball player in the NBA and for both the U.S. and Lebanon’s national basketball team
- Joe Vogel – professional basketball player and member of Lebanon’s national basketball team
- Jackson Vroman – former professional basketball player and member of Lebanon’s national basketball team
- Johnny Manziel – professional football player
Playing card tournament titleholders
- Kassem “Freddy” Deeb – two-time WSOP-bracelet winner
- Ihsan “Sammy” Farha – two-time WSOP-bracelet winner
Writers
- Paula Gunn Allen – a Native American poet and activist
- William Peter Blatty – writer/screenwriter
- Vance Bourjaily – novelist
- Lee Francis – poet
- Khalil Gibran – author and philosopher
- Geoff Johns – comic book writer
- Stephen Karam – playwright
- Raymond Khoury – novelist and screenwriter
- Saree Makdisi – author and literary critic
- Mikha’il Na’ima – author and poet
- Amin al-Rihani – author
- Nassim Nicholas Taleb – essayist